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| Description |
| ADX-88178 is a novel potent, selective, and brain-penetrant positive allosteric modulator of the mGlu4 receptor in rodent models of anxiety, obsessive compulsive disorder (OCD), fear, depression, and psychosis. ADX88178 dose-dependently reduced the number of buried marbles in the marble burying test and increased open-arm exploration in the elevated plus maze (EPM) test, indicative of anxiolytic-like efficacy. |
| Chemical Structure |
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| Chemical Name |
| 5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine |
| SMILES Code |
| CC1=NC(NC2=NC(C3=CNN=C3)=C(C)S2)=NC=C1 |
| Theoretical Analysis |
XingMo Cat#:XM096
Product Name:ADX88178
Synonyms:ADX-88178; ADX 88178; ADX88178.
CAS#:1235318-89-4
Chemical Formula:C12H12N6S
Exact Mass:272.0844
Molecular Weight:272.33
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| Technical Data |
WARNING: This product is for research use only, not for human or veterinary use
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