GNF-6231|1243245-18-2--Shanghai xingMo Biotechnology

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Description

GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50=0.8 nM (Wnt3a Co-culture RGA). GNF-6231 demonstrated excellent pathway inhibition and induced robust antitumor efficacy in a mouse MMTV-WNT1 xenograft tumor model. Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. Wnt signaling is tightly controlled during cellular proliferation, differentiation, and embryonic morphogenesis. Aberrant activation of this pathway plays a critical role in a variety of cancers, such as cutaneous squamous cell carcinoma (SCC), breast cancer, and colorectal cancer.

Chemical Structure

Chemical Name

N-[5-(4-Acetyl-piperazin-1-yl)-pyridin-2-yl]-2-(2'-fluoro-3-methyl-[2,4']bipyridinyl-5-yl)-acetamide

SMILES Code

O=C(NC1=NC=C(N2CCN(C(C)=O)CC2)C=C1)CC3=CN=C(C4=CC(C)=NC=C4)C(C)=F

Theoretical Analysis

XingMo Cat#:XM018
Product Name:GNF-6231
Synonyms:GNF-6231; GNF 6231; GNF6231 .
CAS#:1243245-18-2
Chemical Formula:C₂₄H₂₅FN₆O₂
Exact Mass:448.20
Molecular Weight:448.49
Purity:>98%

Technical Data

Appearance: Solid powder

Purity:>98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

WARNING: This product is for research use only, not for human or veterinary use

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