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| Description |
| CDKI-73 is a potent CDK9 inhibitor with Ki of 4 nM. It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM). The inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin. |
| Chemical Structure |
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| Chemical Name |
| 3-(5-fluoro-4-(4-methyl-2-(methylamino)thiazol-5-yl)pyrimidin-2-ylamino)benzene sulfonamide |
| SMILES Code |
| O=S(C1=CC=CC(NC2=NC=C(F)C(C3=C(C)N=C(NC)S3)=N2)=C1)(N)=O |
| Theoretical Analysis |
XingMo Cat#:XM744
Product Name:CDKI-73
Synonyms:CDKI-73; CDKI 73; CDKI73
CAS#:1421693-22-2
Chemical Formula:C15H15FN6O2S2
Exact Mass:394.0682
Molecular Weight:394.44
Purity:>98%
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| Technical Data |
Purity:
>98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility:
Soluble in DMSO
Shelf Life:
>2 years if stored properly
Drug Formulation:
This drug may be formulated in DMSO
Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
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WARNING: This product is for research use only, not for human or veterinary use
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