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Description
TAK-242 (Resatorvid) is a small molecule TLR4 signaling inhibitor that suppresses LPS-induced production of NO, TNF-alpha and IL-6 in RAW264.7 cells and mouse peritoneal macrophages with IC50 of 1.1-11 nM; also suppresses the production of these cytokines from LPS-stimulated human PBMCs with IC50 of 11-33 nM, suppresses the cytokine production induced by TLR-4 ligands, but not by ligands for TLR2, -3, and -9; binds to Cys747 in the intracellular domain of TLR4, inhibits MyD88-independent pathway as well as MyD88-dependent pathway; demonstrates potent therapeutic effects on mouse sepsis model. 
Chemical Structure
 
Chemical Name
ethyl (6R)-6-[(2-chloro-4-fluorophenyl)sulfamoyl]cyclohexene-1-carboxylate 
Theoretical Analysis
XingMo Cat#:XM769 
Product Name:Resatorvid 
Synonyms:Resatorvid;TAK242;TAK 242 
CAS#:243984-11-4 
Chemical Formula:C15H17ClFNO4S 
Exact Mass:361.8162 
Molecular Weight:361.82 
Purity:98% 
Technical Data

Appearance: solid powder         

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years)

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 ℃ for short term (days to weeks), or -20 ℃ for long term (months).

 



WARNING: This product is for research use only, not for human or veterinary use

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