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Description |
Lufotrelvir is a small molecule prodrug that targets the 3CLpro protease (Mpro), which is used by viruses like SARS-CoV-2 to assemble and multiply. Once administered through intravenous infusion, the compound is cleaved into PF-00835231 to exert its anti-viral effects. Lufotrelvir, developed by Pfizer, was first identified during the SARS outbreak in 2002-2003; it was subsequently shelved as the outbreak was controlled. Now, it is being tested regarding the novel SARS-CoV-2 virus, including studies in conjunction with Remdesivir to treat COVID-19 infection; in vitro data showed synergistic effects on articles published on preprint servers. |
Chemical Structure |
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Chemical Name |
(S)-3-((S)-2-(4-methoxy-1H-indole-2-carboxamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl dihydrogen phosphate |
Theoretical Analysis |
XingMo Cat#:XM802 Product Name:Lufotrelvir Synonyms:PF-07304814,PF07304814 CAS#:2468015-78-1 Chemical Formula:C24H33N4O9P Exact Mass:552.1985 Molecular Weight:552.5208 Purity:98%
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Technical Data |
Solubility: Soluble in DMSO, not in water
Shelf Life:
>2 years if stored properly.
Drug Formulation:
This drug may be formulated in DMSO
Stock Solution Storage:
0 - 4 ℃ for short term (days to weeks), or -20 ℃ for long term (months). |
WARNING: This product is for research use only, not for human or veterinary use
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